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1.
Pakistan Journal of Pharmaceutical Sciences. 2016; 29 (3): 969-977
in English | IMEMR | ID: emr-179569

ABSTRACT

Earthworms are macro invertebrate and have been widely used as therapeutic drugs for thousands of years. In the current research, experiments viz., the antibacterial, antifungal and antioxidant activity of mucus and solvent extracts of Eisenia foetida were conducted to investigate for the first time in Pakistan against human infectious pathogens. Antimicrobial activity of E. foetida against human pathogens underwent investigation through an agar disc diffusion method while an ABTS+ free radical scavenging method assessed the antioxidant activity. The percentage of bacterial and fungal growth was analyzed statistically with One-Way Analysis of Variance [ANOVA]. Results showed that the mucus IV of E. foetida produced a strong potent antibacterial and antifungal activity. Pseudomonas aeruginosa exhibited the highest inhibition zone [33.67 +/- 1.53 mm], followed by Klebsiella pneumonia [30.33 +/- 1.53mm], Penicillium notatum [30 +/- 0.051], Escherichia coli [29 +/- 1 mm], Candida albicans [28.33 +/- 0.54 mm], Staphylococcus aureus [27 +/- 1mm], Serratia marcescens [25.33 +/- 0.58 mm], Aspergillus flavus [25.33 +/- 0.58 mm], Staphylococcus epidermidis [24.33 +/- 0.58 mm], Streptococcus pyogenes [21.67 +/- 1.53 mm], and Aspergillus niger [20.67 +/- 0.53 mm]. Mucus IV of E. foetida also showed the highest antioxidant activity [99. The results clearly indicate that the mucus and solvent extracts contain effective antimicrobial properties and bioactive compounds to inhibit the growth of infectious pathogens. We conclude that mucus extracts of earthworm have significant level of antimicrobial and antioxidant activities and in future could be potentially used against various infectious pathogens

2.
Pakistan Journal of Pharmaceutical Sciences. 2013; 26 (6): 1109-1116
in English | IMEMR | ID: emr-148539

ABSTRACT

Chloroformic and isoamyl alcohol extracts of Cinnnamomum zylanicum, Cuminum cyminum, Curcuma long Linn, Trachyspermum ammi and selected standard antibiotics were investigated for their in vitro antibacterial activity against six human bacterial pathogens. The antibacterial activity was evaluated and based on the zone of inhibition using agar disc diffusion method. The tested bacterial strains were Streptococcus pyogenes, Staphylococcus epidermidis, Klebsiella pneumonia, Staphylococcus aurues, Serratia marcesnces, and Pseudomonas aeruginosa. Ciprofloxacin showed highly significant action against K. pneumonia and S. epidermidis while Ampicillin and Amoxicillin indicated lowest antibacterial activity against tested pathogens. Among the plants chloroform and isoamyl alcohol extracts of C. cyminum, S. aromaticum and C. long Linn had significant effect against P. aeruginosa, S. marcesnces and S. pyogenes. Comparison of antibacterial activity of medicinal herbs and standard antibiotics was also recorded via activity index. Used medicinal plants have various phytochemicals which reasonably justify their use as antibacterial agent


Subject(s)
Anti-Bacterial Agents , Bacteria , Cuminum , Curcuma
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